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Anti-Beta-Catenin Antibody (8B317)
(Synonyms: β-Catenin, Mesc, Catnb, catenin β1, catenin beta 1, Bfc) Copy Product Info
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Synonyms: β-Catenin, Mesc, Catnb, catenin β1, catenin beta 1, Bfc
Catalog No. TMAY-01820 Copy Product Info
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Anti-Beta-Catenin Antibody (8B317) is a Rabbit antibody targeting Beta-Catenin. Anti-Beta-Catenin Antibody (8B317) can be used in ELISA,FCM,ICC/IF,IHC-P.
Anti-Beta-Catenin Antibody
(8B317)
(8B317)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $269 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Beta-Catenin Antibody (8B317) is a Rabbit antibody targeting Beta-Catenin. Anti-Beta-Catenin Antibody (8B317) can be used in ELISA,FCM,ICC/IF,IHC-P. |
| Synonyms | β-Catenin, Mesc, Catnb, catenin β1, catenin beta 1, Bfc |
| Ig Type | Rabbit IgG |
| Clone | 8B317 |
| Reactivity | Human |
| Specificity | Human beta-Catenin No cross-reactivity in ELISA with Mouse CTNNB1 |
| Application | |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human beta-Catenin / CTNNB1 (rh beta-Catenin / CTNNB1; TMPY-02205; P35222-1; Met1-Leu781). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. CTNNB1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, beta-Catenin binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Defects in beta-Catenin can cause colorectal cancer, pilomatrixoma (PTR), medulloblastoma, and ovarian cancer. CTNNB1 is a key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human beta-Catenin / CTNNB1 protein (TMPY-02205) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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