IL-31RA Protein, Mouse, Recombinant (His)

Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 534.00
500 μg	5 days	$ 2,140.00
1 mg	5 days	$ 3,570.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 534.00

500 μg

5 days

$ 2,140.00

1 mg

5 days

$ 3,570.00

Description

Species	Mouse
Expression System	HEK293
Tag	C-His
Accession Number	Q8K5B1-1
Synonyms	GPL, CRL3Glmr, IL-31RA, GLM-R, ZcytoR17, CRL3, PRO21384, GLM-RMGC125346, Gp130-like receptor, IL-31R-alpha, IL-31R-α
Construction	Recombinant Mouse IL-31 RA Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Val19-Thr499.[Accession \|Q8K5B1-1]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 56.3 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.