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(+)-Tetrabenazine

Name: (+)-Tetrabenazine
Brand: TargetMol
SKU: T13134
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13134Cas No. 1026016-83-0

Alias (3R,11bR)-Tetrabenazine, (3R,11bR)-TBZ, (+)-TBZ

(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

(+)-Tetrabenazine

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Purity: 98.69%

Catalog No. T13134Alias (3R,11bR)-Tetrabenazine, (3R,11bR)-TBZ, (+)-TBZCas No. 1026016-83-0

(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$108	In Stock	In Stock
100 mg	$163	-	In Stock
200 mg	$243	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.69%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

(+)-Tetrabenazine AI Summary

(+)-Tetrabenazine demonstrates potent bioactivity with significant affinity for the vesicular monoamine transporter 2 (VMAT2). In vitro, it inhibits [3H]-Methoxytetrabenazine binding to rat brain VMAT2 with a Ki value of 8.1 nM. Additionally, it displaces [3H]DHTBZ from the rat striatum with a Ki value of 4.47 nM, suggesting potential effects on monoamine neurotransmitter release and storage. In vivo studies show that (+)-Tetrabenazine competes with [11C] Methoxytetrabenazine for localization in both the mouse Striatum and Hypothalamus, with an ID/g of 2.26% and 1.71%, respectively. The compound also exhibits antiviral activity against SARS-CoV-2, with an IC50 value greater than 20000 nM when tested at a concentration of 10 uM after 48 hours of exposure to the virus in VERO-6 cells. These properties indicate that (+)-Tetrabenazine may have therapeutic applications in conditions related to monoamine transporter activity and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.
Targets&IC50	Akt3:< 0.5 μM, PKB AKT2:< 0.5 μM, CDC7:<0.3 nM, PKB AKT:< 0.5 μM, Akt1:< 0.5 μM, Akt:< 0.5 μM, PKA:> 5 μM
Synonyms	(3R,11bR)-Tetrabenazine, (3R,11bR)-TBZ, (+)-TBZ

Chemical Properties

Molecular Weight	317.42
Formula	C₁₉H₂₇NO₃
Cas No.	1026016-83-0
Smiles	[H][C@]12CC(=O)[C@H](CC(C)C)CN1CCc1cc(OC)c(OC)cc21
Relative Density.	1.12 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (47.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1504 mL	15.7520 mL	31.5040 mL	157.5200 mL
5 mM	0.6301 mL	3.1504 mL	6.3008 mL	31.5040 mL
10 mM	0.3150 mL	1.5752 mL	3.1504 mL	15.7520 mL
20 mM	0.1575 mL	0.7876 mL	1.5752 mL	7.8760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc