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Pyrroline-5-carboxylate sodium

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Catalog No. T88439Cas No. 72978-16-6

Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.

Pyrroline-5-carboxylate sodium

Pyrroline-5-carboxylate sodium

😃Good
Catalog No. T88439Cas No. 72978-16-6
Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.
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Product Introduction

Bioactivity
Description
Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.
In vitro
Arabidopsis mutant plants deficient in Pyrroline-5-carboxylate catabolism exhibited a cell death-like response (HR) when grown in media containing exogenous Pyrroline-5-carboxylate sodium or proline. Similarly, under oxidative stress conditions, yeast and plant cells showed increased reactive oxygen species (ROS) production and programmed cell death (PCD) due to elevated Pyrroline-5-carboxylate levels. [1]
Chemical Properties
Molecular Weight135.1
FormulaC5H6NNaO2
Cas No.72978-16-6
SmilesO=C(C1=NCCC1)[O-].[Na+]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20 mg/mL (148.04 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM7.4019 mL37.0096 mL74.0192 mL370.0962 mL
5 mM1.4804 mL7.4019 mL14.8038 mL74.0192 mL
10 mM0.7402 mL3.7010 mL7.4019 mL37.0096 mL
20 mM0.3701 mL1.8505 mL3.7010 mL18.5048 mL
50 mM0.1480 mL0.7402 mL1.4804 mL7.4019 mL
100 mM0.0740 mL0.3701 mL0.7402 mL3.7010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTACLinkerPROTAC LinkerPROTAC linkerCompound72978166
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