Shopping Cart

Your shopping cart is currently empty

BML-284

Name: BML-284
Brand: TargetMol
SKU: T3144
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Hot

Catalog No. T3144Cas No. 853220-52-7

Alias Wnt agonist 1

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

BML-284

😃Good

Hot

Purity: 99.92%

Catalog No. T3144Alias Wnt agonist 1Cas No. 853220-52-7

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$55	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$266	In Stock	In Stock
100 mg	$450	In Stock	In Stock
200 mg	$648	-	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
Targets&IC50	TCF-dependent transcriptional activity:700 nM (EC50)
In vitro	Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1]
In vivo	In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1]
Synonyms	Wnt agonist 1

Chemical Properties

Molecular Weight	350.37
Formula	C₁₉H₁₈N₄O₃
Cas No.	853220-52-7
Smiles	COc1cccc(c1)-c1cc(NCc2ccc3OCOc3c2)nc(N)n1
Relative Density.	1.353 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 255 mg/mL (727.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8541 mL	14.2706 mL	28.5413 mL	142.7063 mL
5 mM	0.5708 mL	2.8541 mL	5.7083 mL	28.5413 mL
10 mM	0.2854 mL	1.4271 mL	2.8541 mL	14.2706 mL
20 mM	0.1427 mL	0.7135 mL	1.4271 mL	7.1353 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8541 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4271 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc