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BML-284

Name: BML-284
Brand: TargetMol
SKU: T3144
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3144Cas No. 853220-52-7

Alias Wnt agonist 1

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

BML-284

🥰Excellent

Purity: 99.921%

Catalog No. T3144Alias Wnt agonist 1Cas No. 853220-52-7

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$55	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$266	In Stock	In Stock
100 mg	$450	In Stock	In Stock
200 mg	$648	-	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.921%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
Targets&IC50	TCF-dependent transcriptional activity:700 nM (EC50)
In vitro	Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1]
In vivo	In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1]
Synonyms	Wnt agonist 1

Chemical Properties

Molecular Weight	350.37
Formula	C₁₉H₁₈N₄O₃
Cas No.	853220-52-7
Smiles	COc1cccc(c1)-c1cc(NCc2ccc3OCOc3c2)nc(N)n1
Relative Density.	1.353 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 75 mg/mL (214.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8541 mL	14.2706 mL	28.5413 mL	142.7063 mL
5 mM	0.5708 mL	2.8541 mL	5.7083 mL	28.5413 mL
10 mM	0.2854 mL	1.4271 mL	2.8541 mL	14.2706 mL
20 mM	0.1427 mL	0.7135 mL	1.4271 mL	7.1353 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8541 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc