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NSC 146109 hydrochloride

🥰Excellent
Catalog No. T12257Cas No. 59474-01-0

NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.

NSC 146109 hydrochloride

NSC 146109 hydrochloride

🥰Excellent
Purity: 99.28%
Catalog No. T12257Cas No. 59474-01-0
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$34-In Stock
10 mg$54-In Stock
1 mL x 10 mM (in DMSO)$38-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.28%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.
In vitro
NSC 146109 hydrochloride promotes breast cancer cells to undergo apoptosis through activating p53 and inducing the expression of proapoptotic genes[1].
Chemical Properties
Molecular Weight316.85
FormulaC17H17ClN2S
Cas No.59474-01-0
SmilesCl.Cc1c2ccccc2c(CSC(N)=N)c2ccccc12
Relative Density.1.23g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (252.49 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1561 mL15.7803 mL31.5607 mL157.8034 mL
5 mM0.6312 mL3.1561 mL6.3121 mL31.5607 mL
10 mM0.3156 mL1.5780 mL3.1561 mL15.7803 mL
20 mM0.1578 mL0.7890 mL1.5780 mL7.8902 mL
50 mM0.0631 mL0.3156 mL0.6312 mL3.1561 mL
100 mM0.0316 mL0.1578 mL0.3156 mL1.5780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

proapoptoticp53/MDM2p53NSC-146109 HydrochlorideNSC146109 HydrochlorideNSC-146109NSC146109NSC 146109 HydrochlorideNSC 146109 hydrochlorideNSC 146109MDM-2/p53Inhibitorinhibitbreast cancerApoptosis
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