Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ELOVL6-IN-1 is a potent, selective, and orally active inhibitor of ELOVL6. It exhibits dose-dependent inhibition of mouse ELOVL6 with an IC50 of 0.350 μM and functions as a noncompetitive inhibitor with respect to malonyl-CoA (Ki=994 nM) and palmitoyl-CoA [1].
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Description | ELOVL6-IN-1 is a potent, selective, and orally active inhibitor of ELOVL6. It exhibits dose-dependent inhibition of mouse ELOVL6 with an IC50 of 0.350 μM and functions as a noncompetitive inhibitor with respect to malonyl-CoA (Ki=994 nM) and palmitoyl-CoA [1]. |
In vitro | ELOVL6-IN-1 possesses adequate lipophilicity, enabling it to potentially penetrate intracellular spaces via passive diffusion [1]. |
In vivo | ELOVL6-IN-1, administered orally at a dosage of 10 mg/kg for a duration of 0 to 2 hours, demonstrated significant exposure in both plasma and liver [1]. At dosages of 10 and 30 mg/kg, also administered orally and within the same two-hour time frame, it reduced the elongation index of hepatic lipids [1]. Moreover, when given at a higher dose of 100 mg/kg over a two-day period, ELOVL6-IN-1 decreased the total fatty acid elongation index in the liver [1]. |
Molecular Weight | 495.49 |
Formula | C27H24F3N3O3 |
CAS No. | 712346-06-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ELOVL6-IN-3 712346-06-0 Others inhibitor inhibit