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8-M-PDOT

Name: 8-M-PDOT
Brand: TargetMol
SKU: T10198
Rating: 4.5 (1 reviews)

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Catalog No. T10198Cas No. 134865-70-6

Alias AH-002, 8-Methoxy-2-propionamidotetralin

8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.

8-M-PDOT

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Purity: 99.54%

Catalog No. T10198Alias AH-002, 8-Methoxy-2-propionamidotetralinCas No. 134865-70-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	5 days	5 days
5 mg	$64	6-8 weeks	6-8 weeks
10 mg	$118	-	In Stock
1 mL x 10 mM (in DMSO)	$71	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

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COA LCMS

Product Introduction

Bioactivity

Description	8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
Targets&IC50	MT2 receptor:8.23 (pKi), MT1 receptor:8.95 (pKi)
In vivo	Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect[2].
Animal Research	Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Synonyms	AH-002, 8-Methoxy-2-propionamidotetralin

Chemical Properties

Molecular Weight	233.31
Formula	C₁₄H₁₉NO₂
Cas No.	134865-70-6
Smiles	CCC(=O)NC1CCc2cccc(OC)c2C1
Relative Density.	1.09g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (214.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (21.43 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2861 mL	21.4307 mL	42.8614 mL	214.3071 mL
5 mM	0.8572 mL	4.2861 mL	8.5723 mL	42.8614 mL
10 mM	0.4286 mL	2.1431 mL	4.2861 mL	21.4307 mL
20 mM	0.2143 mL	1.0715 mL	2.1431 mL	10.7154 mL
50 mM	0.0857 mL	0.4286 mL	0.8572 mL	4.2861 mL
100 mM	0.0429 mL	0.2143 mL	0.4286 mL	2.1431 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc