VISTA Protein, Cynomolgus, Recombinant (hFc)

Name: VISTA Protein, Cynomolgus, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-04914
Rating: 4.5 (1 reviews)

(Synonyms: V-set immunoregulatory receptor, C9H10orf54) Copy Product Info

Synonyms: V-set immunoregulatory receptor, C9H10orf54

Catalog No. TMPY-04914 Copy Product Info

VISTA Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is F7F6S6.

Pack Size	Price	USA Stock	Global Stock
5 µg	$76	7-10 days	7-10 days
10 µg	$118	7-10 days	7-10 days
20 µg	$197	7-10 days	7-10 days
50 µg	$398	7-10 days	7-10 days
100 µg	$677	7-10 days	7-10 days
200 µg	$1,130	7-10 days	7-10 days
500 µg	$2,700	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized human IGSF11-His at 2 μg/mL (100 μL/well) can bind Cynomolgus B7H5-hFc, the EC50 of Cynomolgus B7H5-hFc is 0.4-1.3 μg/mL.
Description	VISTA Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is F7F6S6.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	F7F6S6
Construction	A DNA sequence encoding the cynomolgus B7H5 (XP_005565644.1) (Met1-Ala194) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Phe 33
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	V-set immunoregulatory receptor, C9H10orf54
Research Background	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis. An important paralog of this gene is VSIG8.

Chemical Properties

Molecular Weight

44.9 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.