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Urapidil hydrochloride

Name: Urapidil hydrochloride
Brand: TargetMol
SKU: T0088
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0088Cas No. 64887-14-5

Alias Urapidil HCl

Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.

Urapidil hydrochloride

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Purity: 99.58%

Catalog No. T0088Alias Urapidil HClCas No. 64887-14-5

Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$39	In Stock	In Stock
500 mg	$67	In Stock	In Stock
1 g	$97	In Stock	In Stock
2 g	$142	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Urapidil hydrochloride AI Summary

Urapidil hydrochloride exhibits a broad spectrum of bioactive properties. It has shown antiplasmodial activity against Plasmodium falciparum strains 3D7 and W2 with IC50 values of 12,589.25 nM and 10,000.0 nM, respectively, after 72 hours as determined by SYBR green assay. Additionally, it is a potent differential inhibitor of various Plasmodium falciparum lines including 3D7, W2, GB4, D10, and HB3. The compound also demonstrates significant inhibitory effects on multiple bio targets including APE1, lipid storage modulation in Drosophila S3 cells, tau fibril formation, myelin protein 22, histone lysine methyltransferase G9a, Bloom's syndrome helicase (BLM), and the delayed death of the malarial parasite plastid. Furthermore, it shows activity against the interaction between CBF-beta and RUNX1 in acute myeloid leukemia treatment, as well as inhibitory effects on cellular entry of Marburg Virus, Glutaminase (GLS), and Ebola Virus, with potencies ranging from 12.6 nM to over 89,000 nM. Urapidil hydrochloride also exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a 6.88% inhibition rate at 10 μM after 48 hours and in VERO-6 cells with an inhibition of -0.11% at 10 μM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus, as measured by high content imaging. Its activity against SARS-CoV-2 3CL-Pro protease shows an inhibition percentage of 8.021%. Additionally, it has been tested for bioactivity in inhibiting cell viability in SARS-CoV-2 infected Vero E6 cells, displaying an inhibition index of 0.607 relative to the arbidol control. In antifungal assays, Urapidil hydrochloride showed inhibition percentages of 3.19% against Candida albicans and -6.92% against Cryptococcus neoformans. For antibacterial activity, it demonstrated inhibition percentages against Escherichia coli (0.81%), Klebsiella pneumoniae (17.15%), Pseudomonas aeruginosa (19.16%), Acinetobacter baumannii (26.15%), and Staphylococcus aureus MRSA (12.2%)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
Targets&IC50	α1-adrenoceptor:6.13 (pIC50), 5-HT1A receptor:6.4 (pIC50), α2-adrenoceptor:4.38 (pIC50)
Synonyms	Urapidil HCl

Chemical Properties

Molecular Weight	423.94
Formula	C₂₀H₂₉N₅O₃·HCl
Cas No.	64887-14-5
Smiles	Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8.33 mg/mL (19.65 mM), Sonication is recommended.

H2O: 200.5 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3588 mL	11.7941 mL	23.5882 mL	117.9412 mL
5 mM	0.4718 mL	2.3588 mL	4.7176 mL	23.5882 mL
10 mM	0.2359 mL	1.1794 mL	2.3588 mL	11.7941 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1179 mL	0.5897 mL	1.1794 mL	5.8971 mL
50 mM	0.0472 mL	0.2359 mL	0.4718 mL	2.3588 mL
100 mM	0.0236 mL	0.1179 mL	0.2359 mL	1.1794 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc