CGP-53153

Name: CGP-53153
Brand: TargetMol
SKU: T10780
Rating: 4.5 (1 reviews)

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Catalog No. T10780Cas No. 149281-19-6

CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.

CGP-53153

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Catalog No. T10780Cas No. 149281-19-6

CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	2-4 weeks	2-4 weeks
50 mg	$1,980	2-4 weeks	2-4 weeks
100 mg	$2,500	2-4 weeks	2-4 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.
Targets&IC50	5α reductase (human):262 nM , 5α reductase (rat):36 nM
In vitro	CGP-53153 competitively inhibits rat microsomal 5 alpha-reductase from the prostate, with an IC50 of 36 nM, compared to the reference compound finasteride (IC50: 11 nM).
In vivo	CGP-53153, administered orally at a dose of 0.01 mg/kg, significantly reduces T-propionate-induced prostate growth. Further, it notably lowers prostate weight by 31% and 37% at doses of 3 and 10 mg/kg, respectively. A 12-week treatment regimen with CGP-53153 diminishes prostate volume by over 70% in individual dogs without affecting body weight or the weight of any tested organ.

Chemical Properties

Molecular Weight	383.53
Formula	C₂₃H₃₃N₃O₂
Cas No.	149281-19-6
Relative Density.	1.118 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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