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Anti-Gastrokine 1 Antibody (4C630)
🥰Excellent
Catalog No. TMAY-02817
Anti-Gastrokine 1 Antibody (4C630) is a Mouse antibody targeting Gastrokine 1. Anti-Gastrokine 1 Antibody (4C630) can be used in ELISA.
Anti-Gastrokine 1 Antibody (4C630)
Anti-Gastrokine 1 Antibody (4C630)
🥰Excellent
Catalog No. TMAY-02817
Anti-Gastrokine 1 Antibody (4C630) is a Mouse antibody targeting Gastrokine 1. Anti-Gastrokine 1 Antibody (4C630) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Gastrokine 1 Antibody (4C630) is a Mouse antibody targeting Gastrokine 1. Anti-Gastrokine 1 Antibody (4C630) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4C630 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GKN1 / Gastrokine 1 (rh GKN1 / Gastrokine 1; TMPY-00519; Q9NS71; Asn35-Asn199). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterations in gastric cancer cells, that GKN2 may contribute to the homeostasis of gastric epithelial cells by inhibiting GKN1 activity. The loss of GKN1 function contributes to malignant transformation and proliferation of gastric epithelial cells in gastric carcinogenesis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human GKN1 / Gastrokine 1 Protein (TMPY-00519) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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