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Selegiline hydrochloride

Name: Selegiline hydrochloride
Brand: TargetMol
SKU: T5050
Rating: 4.5 (1 reviews)

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Catalog No. T5050Cas No. 14611-52-0

Alias R(-)-Deprenyl hydrochloride

Selegiline hydrochloride is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.

Selegiline hydrochloride

🥰Excellent

Purity: 99.34%

Catalog No. T5050Alias R(-)-Deprenyl hydrochlorideCas No. 14611-52-0

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Purity:99.34%

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Product Introduction

Bioactivity

Description	Selegiline hydrochloride is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.
Targets&IC50	MAO-A:9.06 μM (Ki), MAO-B:0.091 μM (Ki)
Synonyms	R(-)-Deprenyl hydrochloride

Chemical Properties

Molecular Weight	223.74
Formula	C₁₃H₁₈ClN
Cas No.	14611-52-0
Smiles	Cl.C[C@@H](Cc1ccccc1)N(C)CC#C
Relative Density.	0.954g/cm3
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (134.08 mM), Sonication is recommended.

H2O: 20 mg/mL (89.39 mM), Sonication is recommended.

DMSO: 30 mg/mL (134.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (14.75 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4695 mL	22.3474 mL	44.6947 mL	223.4737 mL
5 mM	0.8939 mL	4.4695 mL	8.9389 mL	44.6947 mL
10 mM	0.4469 mL	2.2347 mL	4.4695 mL	22.3474 mL
20 mM	0.2235 mL	1.1174 mL	2.2347 mL	11.1737 mL
50 mM	0.0894 mL	0.4469 mL	0.8939 mL	4.4695 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0447 mL	0.2235 mL	0.4469 mL	2.2347 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc