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(Iso)-Rilmakalim

Name: (Iso)-Rilmakalim
Brand: TargetMol
SKU: T26086L
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T26086LCas No. 184653-89-2

1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one is an isomer of Rilmakalim, a potassium channel opener (PCO), which can activate ATP-sensitive K+ channels in the heart or other tissues

(Iso)-Rilmakalim

🥰Excellent

Purity: 99.86%

Catalog No. T26086LCas No. 184653-89-2

Pack Size	Price	Availability
1 mg	$82	In Stock
5 mg	$181	In Stock
10 mg	$267	In Stock
25 mg	$413	In Stock
50 mg	$592	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.86%

ee:99.36%

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	401.48
Formula	C₂₁H₂₃NO₅S
Cas No.	184653-89-2
Smiles	O[C@@H]1[C@H](C=2C(=CC=C(S(=O)(=O)C3=CC=CC=C3)C2)OC1(C)C)N4C(=O)CCC4
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4908 mL	12.4539 mL	24.9078 mL	124.5392 mL
5 mM	0.4982 mL	2.4908 mL	4.9816 mL	24.9078 mL
10 mM	0.2491 mL	1.2454 mL	2.4908 mL	12.4539 mL
20 mM	0.1245 mL	0.6227 mL	1.2454 mL	6.2270 mL
50 mM	0.0498 mL	0.2491 mL	0.4982 mL	2.4908 mL
100 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2454 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

1((3R,4S)3hydroxy2,2dimethyl6(phenylsulfonyl)chroman4yl)pyrrolidin2one