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Anti-IL-18 Antibody (2S760)
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Catalog No. TMAY-03864
Alias interleukin 18, IL-1g, IL1F4, IL-18, IGIF
Anti-IL-18 Antibody (2S760) is a Mouse antibody targeting IL-18. Anti-IL-18 Antibody (2S760) can be used in ELISA.
Anti-IL-18 Antibody (2S760)
Anti-IL-18 Antibody (2S760)
😃Good
Catalog No. TMAY-03864Alias interleukin 18, IL-1g, IL1F4, IL-18, IGIF
Anti-IL-18 Antibody (2S760) is a Mouse antibody targeting IL-18. Anti-IL-18 Antibody (2S760) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-IL-18 Antibody (2S760) is a Mouse antibody targeting IL-18. Anti-IL-18 Antibody (2S760) can be used in ELISA. |
| Alias | interleukin 18, IL-1g, IL1F4, IL-18, IGIF |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 2S760 |
| Reactivity | Rhesus |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rhesus IL18 / Interleukin-18(Catalog #90011-C07E; NP_001028006.1; Ala 2-Asp 193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rhesus IL18 / Interleukin-18 Protein (TMPY-01928) |
| Antigen Species | Rhesus |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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