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IL-15RA Protein, Human, Recombinant (hFc, Human Cells)

Catalog No. TMPJ-01099
Synonyms: interleukin-15 receptor subunit α, IL15RA, interleukin-15 receptor subunit alpha, IL-15RA, IL-15R-α, α, MGC104179, CD215 antigen, IL-15 receptor subunit α, CD215, IL-15 receptor subunit alpha, IL-15R-alpha, alpha, interleukin 15 receptor

Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
20 μg 5 days $ 190.00
50 μg 5 days $ 350.00
100 μg 5 days $ 527.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml. (QC verified)

Description Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q13261-3
Synonyms interleukin-15 receptor subunit α, IL15RA, interleukin-15 receptor subunit alpha, IL-15RA, IL-15R-α, α, MGC104179, CD215 antigen, IL-15 receptor subunit α, CD215, IL-15 receptor subunit alpha, IL-15R-alpha, alpha, interleukin 15 receptor
Amino Acid Ile31-Thr172
Construction Ile31-Thr172
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.

Molecular Weight 60-75 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.

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Keywords

IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α IL15RA CD-215 interleukin-15 receptor subunit alpha IL-15RA IL-15R-α α MGC104179 CD 215 CD215 antigen IL-15 receptor subunit α CD215 IL-15 receptor subunit alpha MGC 104179 IL-15R-alpha alpha MGC-104179 interleukin 15 receptor recombinant recombinant-proteins proteins protein

 

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