Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | In stock | $ 118.00 | |
20 μg | 5 days | $ 190.00 | |
50 μg | 5 days | $ 350.00 | |
100 μg | 5 days | $ 527.00 |
Biological Information |
Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml. (QC verified)
|
Description | Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells. |
Species | Human |
Expression System | Human Cells |
Tag | C-Fc |
Accession Number | Q13261-3 |
Synonyms | interleukin-15 receptor subunit α, IL15RA, interleukin-15 receptor subunit alpha, IL-15RA, IL-15R-α, α, MGC104179, CD215 antigen, IL-15 receptor subunit α, CD215, IL-15 receptor subunit alpha, IL-15R-alpha, alpha, interleukin 15 receptor |
Amino Acid | Ile31-Thr172 |
Construction | Recombinant Human Interleukin-15 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Ile31-Thr172 is expressed with a human IgG1 Fc tag at the C-terminus. |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
|
Molecular Weight | 60-75 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
IL-15RA Protein, Human, Recombinant (hFc)(Human Cells) interleukin-15 receptor subunit α IL15RA CD-215 interleukin-15 receptor subunit alpha IL-15RA IL-15R-α α MGC104179 CD 215 CD215 antigen IL-15 receptor subunit α CD215 IL-15 receptor subunit alpha MGC 104179 IL-15R-alpha alpha MGC-104179 interleukin 15 receptor recombinant recombinant-proteins proteins protein