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9-cis-Retinal

Name: 9-cis-Retinal
Brand: TargetMol
SKU: T19169
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19169Cas No. 514-85-2

9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin.

9-cis-Retinal

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Catalog No. T19169Cas No. 514-85-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

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Product Introduction

Bioactivity

Description	9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin.
In vitro	b>METHODS: The binding of 9-cis-retinol, 9-cis-retinal, and 9-cis-RA to CRBPI and CRBPII was monitored through fluorescence spectroscopy, and the data were analyzed using nonlinear regression to determine the apparent dissociation constant K'(d) . RESULTS: CRBPI and CRBPII bind to 9-cis-retinol (K'(d), 11nM and 68nM) and 9-cis-retinal (K'(d), 8nM and 5nM) respectively with high affinity; CRBPI or CRBPII have not been observed yet. Significant binding of CRBPII to 9-cis-RA. [1]
In vivo	b>METHODS: After recording baseline ERG, IRBP-deficient mice were allowed to rest for 12 hours, and 0.375 mg of 9-cis-retinal was injected intraperitoneally. ERG before and after were analyzed to test 11-cis-retinal in cones of IRBP-deficient mice. retinal defects. RESULTS: 9-cis-retinal treatment significantly increased cone photoreceptor responses; the cones of IRBP-deficient mice were particularly sensitive to exogenous 9-cis-retinal, and the recovery of cone photoreceptor function to WT levels indicated that IRBP deletion had minimal Cone dysfunction in mice is caused by 11-cis-retinal deficiency. [4]

Chemical Properties

Molecular Weight	284.44
Formula	C₂₀H₂₈O
Cas No.	514-85-2
Smiles	C(=C/C(=C\C=C\C(=C\C=O)\C)/C)\C=1C(C)(C)CCCC1C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (35.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (3.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5157 mL	17.5784 mL	35.1568 mL	175.7840 mL
5 mM	0.7031 mL	3.5157 mL	7.0314 mL	35.1568 mL
10 mM	0.3516 mL	1.7578 mL	3.5157 mL	17.5784 mL
20 mM	0.1758 mL	0.8789 mL	1.7578 mL	8.7892 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc