Shopping Cart

Your shopping cart is currently empty

Tolperisone hydrochloride

Name: Tolperisone hydrochloride
Brand: TargetMol
SKU: T0511
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0511Cas No. 3644-61-9

Alias Tolperisone HCl, Muscalm, Midocalm

Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyelitis, myelopathy, multiple sclerosis, pyramidal tract) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

Tolperisone hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.51%

Catalog No. T0511Alias Tolperisone HCl, Muscalm, MidocalmCas No. 3644-61-9

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	In Stock	In Stock
50 mg	$34	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$69	In Stock	In Stock
500 mg	$118	In Stock	In Stock
1 g	$175	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Tolperisone hydrochloride AI Summary

Tolperisone hydrochloride exhibits a broad range of bioactivities across various assays. It has a potency of 12,589.3 nM in modulating Lamin A splicing and acts as an inhibitor with potencies of 5,623.4 nM against ALDH1A1 and 23,109.3 nM against human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells (absence of CPT). As an antimalarial agent, it shows a delayed death inhibition of the malarial parasite plastid with potencies of 13,459.1 nM at both 48-hour and 96-hour incubations. For gametocytocidal activity, its potency is 22,387.2 nM. In antiviral assays, it exhibits an AC50 of 707.9 nM (or 0.7079 µM) in blocking the entry of the Ebola Virus. Furthermore, Tolperisone hydrochloride significantly inhibits sodium fluorescein uptake in OATP1B1 (96.3%) and OATP1B3 (112.68%) transfected CHO cells at 10 µM. It also inhibits cell viability in Vero E6 cells infected with SARS-CoV-2 at a low MOI of 0.002 after 72 hours, showing an inhibition index of 1.172. It reduces SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM after 48 hours with inhibition percentages of -8.48% and 0.1%, respectively. Lastly, it inhibits SARS-CoV-2 3CL-Pro protease activity by 31.1% at 20 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyelitis, myelopathy, multiple sclerosis, pyramidal tract) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
In vivo	Tolperisone hydrochloride is a safe and effective drug for the treatment of pain-reflex muscle spasms without the typical side effects of central muscle relaxants.Tolperisone blocks calcium ion flow in snail neurons, decreases sodium-potassium ion permeability at frog Lang's ganglion, and has an current passage through Nav1.6 channels (heterologous expression) Inhibitory effect on current through Nav1.6 channel (heterologous expression).
Synonyms	Tolperisone HCl, Muscalm, Midocalm

Chemical Properties

Molecular Weight	281.82
Formula	C₁₆H₂₄ClNO
Cas No.	3644-61-9
Smiles	Cl.CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (195.16 mM), Sonication is recommended.

Ethanol: 52 mg/mL (184.51 mM), Sonication is recommended.

H2O: 51 mg/mL (180.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5484 mL	17.7418 mL	35.4836 mL	177.4182 mL
5 mM	0.7097 mL	3.5484 mL	7.0967 mL	35.4836 mL
10 mM	0.3548 mL	1.7742 mL	3.5484 mL	17.7418 mL
20 mM	0.1774 mL	0.8871 mL	1.7742 mL	8.8709 mL
50 mM	0.0710 mL	0.3548 mL	0.7097 mL	3.5484 mL
100 mM	0.0355 mL	0.1774 mL	0.3548 mL	1.7742 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc