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SMS2-IN-2

🥰Excellent
Catalog No. T7263Cas No. 2241838-28-6
Alias SMS2 inhibitors

SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

SMS2-IN-2

SMS2-IN-2

🥰Excellent
Purity: 98%
Catalog No. T7263Alias SMS2 inhibitorsCas No. 2241838-28-6
SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$116In StockIn Stock
2 mg$169In StockIn Stock
5 mg$288In StockIn Stock
10 mg$449In StockIn Stock
25 mg$739In StockIn Stock
50 mg$987-In Stock
100 mg$1,390-In Stock
1 mL x 10 mM (in DMSO)$295In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
Targets&IC50
SMS2:100 nM (IC50), SMS1:56 μM (IC50)
SynonymsSMS2 inhibitors
Chemical Properties
Molecular Weight369.78
FormulaC19H13ClFN3O2
Cas No.2241838-28-6
SmilesFc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1
Relative Density.1.423 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (676.08 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.52 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7043 mL13.5216 mL27.0431 mL135.2155 mL
5 mM0.5409 mL2.7043 mL5.4086 mL27.0431 mL
10 mM0.2704 mL1.3522 mL2.7043 mL13.5216 mL
20 mM0.1352 mL0.6761 mL1.3522 mL6.7608 mL
50 mM0.0541 mL0.2704 mL0.5409 mL2.7043 mL
100 mM0.0270 mL0.1352 mL0.2704 mL1.3522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SMS2-IN-2SMS-2-IN-2SMS2IN2SMS2 IN 2SMS2Inhibitorinhibit
Related Tags: buy SMS2-IN-2 | purchase SMS2-IN-2 | SMS2-IN-2 cost | order SMS2-IN-2 | SMS2-IN-2 chemical structure | SMS2-IN-2 formula | SMS2-IN-2 molecular weight
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