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Volinanserin

Name: Volinanserin
Brand: TargetMol
SKU: T5389
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5389Cas No. 139290-65-6

Alias MDL100907, M 100907

Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors.

Volinanserin

🥰Excellent

Purity: 99.95%

Catalog No. T5389Alias MDL100907, M 100907Cas No. 139290-65-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$126	In Stock	In Stock
25 mg	$245	In Stock	In Stock
50 mg	$317	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$589	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.95%

Color:White to Yellow

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COA

Product Introduction

Bioactivity

Description	Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma receptors.
Targets&IC50	5-HT2 receptor:0.36 nM (Ki)
In vitro	Volinanserindemonstrated low nanomolar or subnanomolar binding in vitro at the 5-HT2A receptor and showed a > 100-fold separation from all other receptors measured. Volinanserinhad subnanomolar potency as a 5-HT2A antagonist in vitro in reversing 5-HT-stimulated inositol phosphate accumulation in NIH 3T3 cells transfected with the rat 5-HT2A receptor [2].
In vivo	In mice, Volinanserinblocked amphetamine-stimulated locomotion at doses that did not significantly affect apomorphine-stimulated climbing behavior. When administered chronically, Volinanserinselectively reduced the number of spontaneously active A10 neurons [1]. In vivo, Volinanserinpotently inhibited 5-methoxy-N, N-dimethyltryptamine-induced head twitches in mice or 5-hydroxytryptophan-induced head twitches in rats. In vivo, functional tests in mice revealed a > 500-fold separation between doses that produced 5-HT2A antagonism and doses that produced alpha 1-adrenergic or striatal D2 antagonism [2].
Synonyms	MDL100907, M 100907

Chemical Properties

Molecular Weight	373.46
Formula	C₂₂H₂₈FNO₃
Cas No.	139290-65-6
Smiles	COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC
Relative Density.	1.15g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (334.71 mM), Sonication is recommended.

Ethanol: 18 mg/mL (48.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6777 mL	13.3883 mL	26.7766 mL	133.8831 mL
5 mM	0.5355 mL	2.6777 mL	5.3553 mL	26.7766 mL
10 mM	0.2678 mL	1.3388 mL	2.6777 mL	13.3883 mL
20 mM	0.1339 mL	0.6694 mL	1.3388 mL	6.6942 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0536 mL	0.2678 mL	0.5355 mL	2.6777 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3388 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc