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DCC-3116

Name: DCC-3116
Brand: TargetMol
SKU: T86167
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T86167Cas No. 2543673-19-2

Alias DCC3116

DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.

DCC-3116

🥰Excellent

Purity: 98.55%

Catalog No. T86167Alias DCC3116Cas No. 2543673-19-2

DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
5 mg	$158	In Stock	In Stock
10 mg	$248	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.55%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.
In vitro	100 nM DCC-3116 alone inhibited NCI-H2122 and Calu-1 cell proliferation and reduced pS318-ATG13 expression, and DCC-3116 in combination with sotorasib showed synergistic inhibition of human lung cancer cell proliferation driven by the KRAS G12C mutation in vitro. [1]
In vivo	Daily oral or intraperitoneal administration of 3 or 30 mg/kg DCC-3116 for 56 consecutive days alone or in combination with Sotorasib inhibited tumor growth in a mouse model of NSCLC lung cancer. [1]
Synonyms	DCC3116

Chemical Properties

Molecular Weight	535.61
Formula	C₂₆H₃₆F₃N₇O₂
Cas No.	2543673-19-2
Smiles	O=C1N(CCOCC1)CCCNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3CC)N4CCN(C)CC4
Relative Density.	1.266 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL(186.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8670 mL	9.3352 mL	18.6703 mL	93.3515 mL
5 mM	0.3734 mL	1.8670 mL	3.7341 mL	18.6703 mL
10 mM	0.1867 mL	0.9335 mL	1.8670 mL	9.3352 mL
20 mM	0.0934 mL	0.4668 mL	0.9335 mL	4.6676 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8670 mL
100 mM	0.0187 mL	0.0934 mL	0.1867 mL	0.9335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc