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Anti-Granzyme B/GZMB Antibody (2G111)
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Catalog No. TMAH-00526
Anti-Granzyme B/GZMB Antibody (2G111) is an antibody targeting Granzyme B/GZMB. Anti-Granzyme B/GZMB Antibody (2G111) can be used in ELISA, IHC, IF.
Anti-Granzyme B/GZMB Antibody (2G111)
Anti-Granzyme B/GZMB Antibody (2G111)
😃Good
Catalog No. TMAH-00526
Anti-Granzyme B/GZMB Antibody (2G111) is an antibody targeting Granzyme B/GZMB. Anti-Granzyme B/GZMB Antibody (2G111) can be used in ELISA, IHC, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, IHC, IF Reactivity: Human |
| Ig Type | Rabbit IgG |
| Clone | 2G111 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00526 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 2. Immunofluorescence staining of Hela Cells with TMAH-00526 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IHC, IF |
| Recommended Dose | IHC:1:50-1:200; IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. Cytolytic granule. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Granzyme B |
| Antigen Species | Human |
| Gene ID | 3002 |
| Uniprot ID | |
| Biology Area | Cell biology, Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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