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LLY-283

Name: LLY-283
Brand: TargetMol
SKU: T15767
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15767Cas No. 2040291-27-6

LLY-283 is a potent, selective, and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, exhibiting an IC50 of 22 nM and a Kd of 6 nM for the PRMT5:MEP50 complex, and demonstrates antitumor activity.

LLY-283

🥰Excellent

Purity: 99.49%

Catalog No. T15767Cas No. 2040291-27-6

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$79	In Stock
10 mg	Preferential	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Purity:99.49%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	LLY-283 is a potent, selective, and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, exhibiting an IC50 of 22 nM and a Kd of 6 nM for the PRMT5:MEP50 complex, and demonstrates antitumor activity.
Targets&IC50	PRMT5:22 nM, MEP50:22 nM, PRMT5:(ki)6 nM, MEP50:(ki)6 nM
In vitro	LLY-283 is a potent, oral, and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, and a Kd of 6 nM for the PRMT5:MEP50 complex in vitro; LLY-283 inhibits A375 cell proliferation with an IC50 of 46 nM[1].
In vivo	LLY-283 administered orally at a dose of 20 mg/kg daily significantly inhibits tumor growth in A375 cell-bearing mice over a 28-day treatment period[1].

Chemical Properties

Molecular Weight	342.35
Formula	C₁₇H₁₈N₄O₄
Cas No.	2040291-27-6
Smiles	[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H](O)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 3.57 mg/mL (10.43 mM), Sonication and heating to 60℃ are recommended.

DMSO: 112.5 mg/mL (328.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9210 mL	14.6049 mL	29.2099 mL	146.0494 mL
5 mM	0.5842 mL	2.9210 mL	5.8420 mL	29.2099 mL
10 mM	0.2921 mL	1.4605 mL	2.9210 mL	14.6049 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1460 mL	0.7302 mL	1.4605 mL	7.3025 mL
50 mM	0.0584 mL	0.2921 mL	0.5842 mL	2.9210 mL
100 mM	0.0292 mL	0.1460 mL	0.2921 mL	1.4605 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc