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Rotigotine Hydrochloride

Name: Rotigotine Hydrochloride
Brand: TargetMol
SKU: T21446
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21446Cas No. 125572-93-2

Alias Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923

Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.

Rotigotine Hydrochloride

🥰Excellent

Purity: 99.56%

Catalog No. T21446Alias Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923Cas No. 125572-93-2

Pack Size	Price	Availability
5 mg	$37	In Stock
10 mg	$54	In Stock
25 mg	$88	In Stock
50 mg	$118	In Stock
100 mg	$162	In Stock
200 mg	$239	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock

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Purity:99.56%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.
Targets&IC50	α1B:273 nM (Ki), 5-HT7 receptor:86 nM (Ki), D5 receptor:4-15 nM (Ki), α2B:27 nM (Ki), D1 receptor:83 nM (Ki), α2A:338 nM (Ki), D4 receptor:4-15 nM (Ki), 5-HT1A receptor:30 nM (Ki), D3 receptor:0.71 nM (Ki), α1A:176 nM (Ki), D2 receptor:4-15 nM (Ki)
Synonyms	Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923

Chemical Properties

Molecular Weight	351.93
Formula	C₁₉H₂₆ClNOS
Cas No.	125572-93-2
Smiles	Cl.CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
Relative Density.	1.2 g/cm3 at 20℃
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (198.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8415 mL	14.2074 mL	28.4147 mL	142.0737 mL
5 mM	0.5683 mL	2.8415 mL	5.6829 mL	28.4147 mL
10 mM	0.2841 mL	1.4207 mL	2.8415 mL	14.2074 mL
20 mM	0.1421 mL	0.7104 mL	1.4207 mL	7.1037 mL
50 mM	0.0568 mL	0.2841 mL	0.5683 mL	2.8415 mL
100 mM	0.0284 mL	0.1421 mL	0.2841 mL	1.4207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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