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MG 149

Name: MG 149
Brand: TargetMol
SKU: T6584
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6584Cas No. 1243583-85-8

Alias Tip60 HAT inhibitor, MG149

MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).

MG 149

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Purity: 99.86%

Catalog No. T6584Alias Tip60 HAT inhibitor, MG149Cas No. 1243583-85-8

MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$68	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$342	In Stock	In Stock
50 mg	$546	In Stock	In Stock
100 mg	$787	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

MG 149 AI Summary

MG 149 exhibits a broad range of bioactivities, prominently related to the inhibition of various histone acetyltransferases (HATs) including Tip60, PCAF, and p300 HAT domains. It competitively inhibits Tip60 with a Kis value of 54.0 µM and uncompetitively with a Kii value of 78.0 µM, effectively inhibiting Tip60-mediated histone acetylation in HeLa nuclear extracts, particularly impacting histone H3 and H4 acetylation with inhibition percentages exceeding 50.0%. Additionally, it inhibits the human His-tagged MOF enzyme with 100% inhibition at concentrations of 50 µM and 100 µM and shows IC50 values of 15000.0 nM and 27000.0 nM in respective radioactive acetylation and alphascreen assays. Beyond its activity in epigenetic regulation, MG 149 demonstrates potent bioactivity in various cell proliferation assays, cell lines including Plasmodium falciparum and ATL, as well as antagonism of the NFkB signaling pathway and cytotoxicity counterscreen, with potency in the nanomolar range. It also exhibits the ability to activate potato 5-lipoxygenase, evidenced by a fold change (FC) value of 3.0 at a 50 µM concentration. Moreover, it inhibits human COX2 with less than 50% inhibition using arachidonic acid as a substrate. Overall, MG 149 targets multiple biological pathways, suggesting potential as a versatile modulator of both epigenetic and cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
Targets&IC50	Tip60:74 μM, MOF:47 μM
Synonyms	Tip60 HAT inhibitor, MG149

Chemical Properties

Molecular Weight	340.46
Formula	C₂₂H₂₈O₃
Cas No.	1243583-85-8
Smiles	CCCCCCCc1ccc(CCc2cccc(O)c2C(O)=O)cc1
Relative Density.	1.100 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 63 mg/mL (185.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 255 mg/mL (748.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9372 mL	14.6860 mL	29.3720 mL	146.8601 mL
5 mM	0.5874 mL	2.9372 mL	5.8744 mL	29.3720 mL
10 mM	0.2937 mL	1.4686 mL	2.9372 mL	14.6860 mL
20 mM	0.1469 mL	0.7343 mL	1.4686 mL	7.3430 mL
50 mM	0.0587 mL	0.2937 mL	0.5874 mL	2.9372 mL
100 mM	0.0294 mL	0.1469 mL	0.2937 mL	1.4686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc