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EGFR-IN-11

Name: EGFR-IN-11
Brand: TargetMol
SKU: T11158
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11158Cas No. 2463200-44-2

EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

EGFR-IN-11

🥰Excellent

Purity: 99.93%

Catalog No. T11158Cas No. 2463200-44-2

EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$83	In Stock
10 mg	$141	In Stock
25 mg	$223	In Stock
50 mg	$310	In Stock
100 mg	$412	In Stock
1 mL x 10 mM (in DMSO)	$105	In Stock

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Purity:99.93%

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COA LCMS HNMR LCMS HPLC LCMS

Product Introduction

Bioactivity

Description	EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.
Targets&IC50	EGFR (L858R/T790M/C797S):18 nM
In vitro	EGFR-IN-11 (0.1 nM-10 µM) shows anti-proliferation with IC50s of 0.88 nM, 0.20 µM and 2.91 μM for HCC827, H1975 and A549 cells. EGFR-IN-11 (10nM-10 µM) suppresses the phosphorylation of EGFR in a concentration-dependent manner in the HCC827, H1975 and A549 cells[1].

Chemical Properties

Molecular Weight	573.71
Formula	C₂₉H₃₅N₉O₂S
Cas No.	2463200-44-2
Smiles	CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (196.1 mM ), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7430 mL	8.7152 mL	17.4304 mL	87.1520 mL
5 mM	0.3486 mL	1.7430 mL	3.4861 mL	17.4304 mL
10 mM	0.1743 mL	0.8715 mL	1.7430 mL	8.7152 mL
20 mM	0.0872 mL	0.4358 mL	0.8715 mL	4.3576 mL
50 mM	0.0349 mL	0.1743 mL	0.3486 mL	1.7430 mL
100 mM	0.0174 mL	0.0872 mL	0.1743 mL	0.8715 mL

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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