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KL4-219A
🥰Excellent
Catalog No. T204093
Alias KL4219A
KL4-219A is a selective covalent degrader of the oncogenic transcription factor MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner by targeting intrinsically disordered C203 and D205 residues.
KL4-219A
🥰Excellent
Purity: 99.68%
Catalog No. T204093Alias KL4219A
KL4-219A is a selective covalent degrader of the oncogenic transcription factor MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner by targeting intrinsically disordered C203 and D205 residues.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $164 | In Stock | |
| 5 mg | $361 | In Stock | |
| 10 mg | $539 | In Stock | |
| 25 mg | $996 | In Stock | |
| 50 mg | $1,597 | In Stock | |
| 100 mg | $2,556 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KL4-219A is a selective covalent degrader of the oncogenic transcription factor MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner by targeting intrinsically disordered C203 and D205 residues. |
| Targets&IC50 | HDAC11:4.5 nM |
| In vitro | KL4-219A potently inhibits HDAC11 in human cancer cell lines such as MDA-MB-231 and HCT116, with an IC₅₀ of 4.5 nM. KL4-219A increases H3K9 acetylation levels and boosts IL-10 expression in vitro. KL4-219A also suppresses MYC expression in immune cells and modulates pathways related to inflammation and metabolism[1]. |
| In vivo | In C57BL/6J mice, KL4-219A was administered intraperitoneally at 50 mg/kg daily for 14 days, resulting in marked downregulation of MYC and upregulation of IL-10 in tumor tissue. In a breast cancer xenograft model, KL4-219A significantly reduced tumor volume compared to vehicle controls, with no observed toxicity[1]. |
| Alias | KL4219A |
| Molecular Weight | 356.48 |
| Formula | C20H24N2O2S |
| Smiles | COC(C=C1)=CC=C1N2C3=CC=CC=C3[C@@]4(N([S@](C(C)(C)C)=O)C4)C2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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