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Anti-CD274 Monoclonal Antibody (9E527)
(Synonyms: PD-L1, PDL1, PDCD1LG1, PDCD1L1, B7H1, B7-H) Copy Product Info
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Synonyms: PD-L1, PDL1, PDCD1LG1, PDCD1L1, B7H1, B7-H
Catalog No. TMAT-0352 Copy Product Info
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Anti-CD274 Monoclonal Antibody (9E527) is a Mouse antibody targeting CD274. Anti-CD274 Monoclonal Antibody (9E527) can be used in IHC,FCM.
Anti-CD274 Monoclonal Antibody
(9E527)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-CD274 Monoclonal Antibody (9E527) is a Mouse antibody targeting CD274. Anti-CD274 Monoclonal Antibody (9E527) can be used in IHC,FCM. |
| Synonyms | PD-L1, PDL1, PDCD1LG1, PDCD1L1, B7H1, B7-H |
| Ig Type | IgG2b |
| Clone | 9E527 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CD274 |
| Gene ID | |
| Protein Name | Programmed cell death 1 ligand 1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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