Human IL-31 RA, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-31, His Tag with an affinity constant of 0.715 nM as determined in SPR assay (Biacore T200).

IL-31 Protein, Cynomolgus, Recombinant (N-His) is expressed in HEK293 Cells. The accession number is G7PJ78-1.

Cynomolgus

HEK293 Cells

interleukin 31

Leu27-Thr163

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells.