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RECQL5-IN-1

Name: RECQL5-IN-1
Brand: TargetMol
SKU: T63899
Rating: 4.5 (1 reviews)

Catalog No. T63899 Copy Product Info

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RECQL5-IN-1 is an orally active RECQL5 inhibitor (IC50 = 46.3 nM) that simultaneously targets both enzymatic and non-enzymatic domains. RECQL5-IN-1 stabilizes the interaction between RECQL5 and RAD51 proteins, disrupting homologous recombination repair (HRR), thereby selectively killing cancer cells that express RECQL5.

RECQL5-IN-1

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Catalog No. T63899

Cas No. 2718170-45-5

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,310	6-8 weeks	6-8 weeks
50 mg	$1,710	6-8 weeks	6-8 weeks
100 mg	$2,730	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	RECQL5-IN-1 is an orally active RECQL5 inhibitor (IC50 = 46.3 nM) that simultaneously targets both enzymatic and non-enzymatic domains. RECQL5-IN-1 stabilizes the interaction between RECQL5 and RAD51 proteins, disrupting homologous recombination repair (HRR), thereby selectively killing cancer cells that express RECQL5.
Targets&IC50	RECQL5:46.3 nM
In vitro	Methods: RECQL5-IN-1 (0, 10, 20 μM) was added to MCF-7 cells, which were incubated for 72 hours; apoptosis was then assessed by flow cytometry. Results: RECQL5-IN-1 significantly induced apoptosis in MCF-7 cells. [1]
In vivo	Methods: To investigate the antitumor efficacy of RECQL5-IN-1, Nude mice were subcutaneously inoculated with MCF-7 RECQL5-WT cells and administered RECQL5-IN-1 (50 mg/kg) orally via gavage every other day for a total of 30 days. Results: RECQL5-IN-1 significantly inhibited the growth of RECQL5-WT tumors. [1]

Chemical Properties

Molecular Weight	552.49
Formula	C₂₅H₁₈F₆N₄O₂S
Cas No.	2718170-45-5
Smiles	[C@@H](NC(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C=2OC(SCC3=CC=CC=C3)=NN2)C4=CC=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (362 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8100 mL	9.0499 mL	18.0999 mL	90.4994 mL
5 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.0999 mL
10 mM	0.1810 mL	0.9050 mL	1.8100 mL	9.0499 mL
20 mM	0.0905 mL	0.4525 mL	0.9050 mL	4.5250 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8100 mL
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9050 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

RECQL5-IN-1

RECQL5-IN-1

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