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I-152

Name: I-152
Brand: TargetMol
SKU: T75128
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75128Cas No. 311343-11-0

Alias I152

I-152 is a coupling of N-acetylcysteine and β-mercaptoethylamine. I-152 has antiproliferative, antiviral, and immunomodulatory activities. I-152 is used in the study of viral infections because it activates NRF2 and ATF4 signaling.

I-152

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Purity: 98.36%

Catalog No. T75128Alias I152Cas No. 311343-11-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	-	In Stock
5 mg	$210	7-10 days	7-10 days
10 mg	$360	7-10 days	7-10 days
25 mg	$619	7-10 days	7-10 days
50 mg	$993	7-10 days	7-10 days
100 mg	$1,590	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.36%

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COA

Product Introduction

Bioactivity

Description	I-152 is a coupling of N-acetylcysteine and β-mercaptoethylamine. I-152 has antiproliferative, antiviral, and immunomodulatory activities. I-152 is used in the study of viral infections because it activates NRF2 and ATF4 signaling.
In vitro	When I-152 is treated with RAW 264.7 cells at a concentration of 1 mM, it decreases the level of NRF2 mRNA after 1 h or 2 h; treatment for 0-60 min not only decreases the levels of NRF2 and p53, but also increases the expression of ATF4. In addition, at concentrations of 0.062, 0.125, 0.25, or 1 mM, I-152 was able to increase the levels of Gclc mRNA and Chac1 mRNA after 6 h or 24 h, and increase Chop mRNA expression after 6 h. The expression of Chac1 mRNA was also increased at concentrations of 0.062, 0.125, 0.25, or 1 mM. I-152 also increased GSH levels in RAW 264.7 cells when treated at concentrations of 0.062, 0.125, 0.25, or 1 mM for 2 hours. At a concentration of 1 mM, I-152 treatment for 1 h, 2 h, 6 h and 24 h activated the expression of ATF4 mRNA in RAW 264.7 cells; whereas treatment for 24 h and 48 h produced cytotoxicity and inhibited the growth of RAW 264.7 cells. [1]
Synonyms	I152

Chemical Properties

Molecular Weight	264.37
Formula	C₉H₁₆N₂O₃S₂
Cas No.	311343-11-0
Smiles	[C@H](C(NCCSC(C)=O)=O)(NC(C)=O)CS
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (302.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7826 mL	18.9129 mL	37.8258 mL	189.1289 mL
5 mM	0.7565 mL	3.7826 mL	7.5652 mL	37.8258 mL
10 mM	0.3783 mL	1.8913 mL	3.7826 mL	18.9129 mL
20 mM	0.1891 mL	0.9456 mL	1.8913 mL	9.4564 mL
50 mM	0.0757 mL	0.3783 mL	0.7565 mL	3.7826 mL
100 mM	0.0378 mL	0.1891 mL	0.3783 mL	1.8913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc