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MSC2360844

Name: MSC2360844
Brand: TargetMol
SKU: T12115
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12115Cas No. 1305267-37-1

MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).

MSC2360844

🥰Excellent

Purity: 99.9%

Catalog No. T12115Cas No. 1305267-37-1

MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$118	In Stock
10 mg	$191	In Stock
25 mg	$373	In Stock
50 mg	$598	In Stock
100 mg	$948	In Stock
200 mg	$1,270	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.9%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
Targets&IC50	PI3Kδ:145 nM
In vitro	MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1].
In vivo	in a murine SLE model，MSC2360844 ameliorates disease manifestations [1].

Chemical Properties

Molecular Weight	526.58
Formula	C₂₆H₂₇FN₄O₅S
Cas No.	1305267-37-1
Smiles	Fc1cccc2-c3c(CS(=O)(=O)c12)c(nn3-c1ccc(CN2CCOCC2)cc1)C(=O)N1CCOCC1
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (170.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8990 mL	9.4952 mL	18.9905 mL	94.9523 mL
5 mM	0.3798 mL	1.8990 mL	3.7981 mL	18.9905 mL
10 mM	0.1899 mL	0.9495 mL	1.8990 mL	9.4952 mL
20 mM	0.0950 mL	0.4748 mL	0.9495 mL	4.7476 mL
50 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8990 mL
100 mM	0.0190 mL	0.0950 mL	0.1899 mL	0.9495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc