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Ceftaroline fosamil inner salt

Catalog No. T39816 CAS 229016-73-3

Synonyms: TAK-599 free acid, PPI0903freeacid

Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.

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Ceftaroline fosamil inner salt Chemical Structure

Ceftaroline fosamil inner salt, CAS 229016-73-3

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.
In vivo	Ceftaroline fosamil inner salt (s.c.) demonstrates efficacy in mitigating systemic infections induced by S. aureus N133 in mice, evidenced by ED50 values ranging from 1.60 to 2.37 mg/kg[1]. At a dosage of 10 mg/kg (s.c.), it is quickly metabolized in the bloodstream of rats and monkeys, transitioning efficiently into T-91825[1].

Synonyms	TAK-599 free acid, PPI0903freeacid
Molecular Weight	684.67
Formula	C22H21N8O8PS4
CAS No.	229016-73-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ishikawa T, et, al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem. 2003 May 29;11(11):2427-37. 2. Jacqueline C, et, al. In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. Antimicrob Agents Chemother. 2007 Sep;51(9):3397-400. 3. Parish D, et, al. Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Curr Opin Investig Drugs. 2008 Feb;9(2):201-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ceftaroline fosamil inner salt 229016-73-3 TAK-599 free acid PPI0903freeacid Ceftaroline fosamil inner inhibitor inhibit

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