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Thioquinapiperifil dihydrochloride

Catalog No. T9773 CAS 204077-66-7

Synonyms: KF-31327

Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.

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Thioquinapiperifil dihydrochloride Chemical Structure

Thioquinapiperifil dihydrochloride, CAS 204077-66-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 155.00
5 mg	In stock	$ 383.00
10 mg	In stock	$ 569.00
25 mg	In stock	$ 917.00
50 mg	In stock	$ 1,250.00
100 mg	In stock	$ 1,690.00
500 mg	In stock	$ 3,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 441.00

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Purity: 98.73%

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Description	Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.
Targets&IC50	PDE5:0.074 nM, PDE1:380 nM, PDE2:670 nM, PDE3:38 nM, PDE4:800 nM
In vitro	Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) inhibits platelet aggregation in a concentration-dependent manner. In the absence of nitroglycerin, higher concentrations of 1 and 10 μM of KF31327 are inhibits platelet aggregation in a concentration-dependent manner.[2] Thioquinapiperifil dihydrochloride (KF31327) shows a significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of KF31327-treated cells is 0.95±0.17 pmol/10 8 cells.[2]

Synonyms	KF-31327
Molecular Weight	485.05
Formula	C24H29ClN6OS
CAS No.	204077-66-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (215.7 mM), Sonication is recommended.

References and Literature

1. Uchiyama N, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008;56(9):1331-1334. 2. Hirose R, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001;431(1):17-24. 3. Orfi L, et al. Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs. Curr Med Chem. 2004;11(19):2549-255

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This product is contained In the following compound libraries：

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Keywords

Thioquinapiperifil dihydrochloride 204077-66-7 Metabolism PDE KF 31327 KF31327 Thioquinapiperifil Thioquinapiperifil Dihydrochloride KF-31327 inhibitor inhibit

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