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Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486) with significant in vivo bactericidal activities.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | Inquiry | Inquiry |
| Description | Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486) with significant in vivo bactericidal activities. |
| In vivo | Fobrepodacin administered through oral gavage at doses of 10, 30, and 100 mg/kg once daily, five days a week for four weeks, significantly reduces the mycobacterial burden in a model of chronic tuberculosis infection in six-week-old female BALB/c and C57BL/6 mice, both uninfected and infected with M. tuberculosis (Erdman). Additionally, a regimen of 100 mg/kg once daily for eight weeks enhances the bactericidal efficacy of antimycobacterial drugs in these models[1]. |
| Synonyms | SPR720, pVXc-486 |
| Molecular Weight | 508.44 |
| Formula | C21H26FN6O6P |
| Cas No. | 1384984-31-9 |
| Smiles | CCNC(=O)Nc1nc2cc(c(F)c([C@H]3CCCO3)c2[nH]1)-c1cnc(nc1)C(C)(C)OP(O)(O)=O |
| Relative Density. | 1.496 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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