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trans-Benzylideneacetone

Name: trans-Benzylideneacetone
Brand: TargetMol
SKU: TCS1554
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TCS1554Cas No. 1896-62-4

Alias Acetocinnamone

trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.

trans-Benzylideneacetone

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Purity: 97.48%

Catalog No. TCS1554Alias AcetocinnamoneCas No. 1896-62-4

trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$33	-	In Stock
5 g	$54	-	In Stock
10 g	$79	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.48%

Appearance:Viscous

Color:White

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COA LCMS HPLC HNMR

Product Introduction

trans-Benzylideneacetone AI Summary

trans-Benzylideneacetone exhibits a diverse range of bioactivities across different biological systems and assays. It inhibits UV-induced mutagenesis in Escherichia coli WP2uvrA with an IC50 value of 501187.23 nM and demonstrates the ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells with a CD value of 15.0 μM, suggesting antioxidant properties and a potential role in cellular detoxification pathways. The compound has in vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line with an IC50 of 17000.0 nM and exhibits cytotoxicity against various human cell lines, including KB, KB-VCR, and A549, with IC50 values of 5.3, 5.6, and 2.8 μg/mL, respectively. In terms of antiproliferative activity, trans-Benzylideneacetone shows IC50 values greater than 20000.0 nM against HL60, HeLa, and JR8 cells. Acute toxicity studies in rats indicate an LD50 value of 1.985 mg.kg-1, highlighting its high toxicity. The compound also displays inhibitory effects in NCI human tumor cell line growth inhibition assays with GI50 values between 14028.14 nM and 100000 nM across multiple cell lines, including Breast, Renal, Lung, Melanoma, Colon, Leukemia, and Ovarian. trans-Benzylideneacetone inhibits tyrosyl-DNA phosphodiesterase (TDP1) and ELG1-dependent DNA repair mechanisms and activates glucocorticoid receptor signaling. It shows insecticidal activity against Plutella xylostella larvae with an LC50 of 5735.6 ppm and inhibits immune responses, phenoloxidase activity, and PLA2 in Spodoptera exigua larvae with IC50 values of 31350.0 nM, 38310.0 nM, and 33310.0 nM, respectively. Against Culex quinquefasciatus larvae, it has an LC50 of 479.0 μmol/dm3 after 24 hours. The compound demonstrates antioxidant activity as a DPPH radical scavenger with an IC50 of 302180000.0 nM. In human Raji cells expressing EBV-EA, it inhibits TPA-induced EBV-EA activation with an IC50 of 129.0 molar ratio. trans-Benzylideneacetone also shows drug metabolism-related activity, demonstrating 60.0% reactivity in glutathione conjugation at pH 7.4 after 4 hours. It acts as a substrate for enzyme activities at ADH101 and ADH105, exhibiting varying nmol/min/mg enzymatic rates under different experimental conditions. Lastly, trans-Benzylideneacetone inhibits the LuxR quorum sensing system in Vibrio harveyi BB120, showing 78.0% inhibition of autoinducer-2 induced LuxR activity at 100 μM for 16 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.
Synonyms	Acetocinnamone

Chemical Properties

Molecular Weight	146.19
Formula	C₁₀H₁₀O
Cas No.	1896-62-4
Smiles	CC(=O)\C=C\c1ccccc1
Relative Density.	1.014 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (376.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8404 mL	34.2021 mL	68.4041 mL	342.0207 mL
5 mM	1.3681 mL	6.8404 mL	13.6808 mL	68.4041 mL
10 mM	0.6840 mL	3.4202 mL	6.8404 mL	34.2021 mL
20 mM	0.3420 mL	1.7101 mL	3.4202 mL	17.1010 mL
50 mM	0.1368 mL	0.6840 mL	1.3681 mL	6.8404 mL
100 mM	0.0684 mL	0.3420 mL	0.6840 mL	3.4202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc