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Ombuin

Name: Ombuin
Brand: TargetMol
SKU: TN2010
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2010Cas No. 529-40-8

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.

Ombuin

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Purity: 99.71%

Catalog No. TN2010Cas No. 529-40-8

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$332	In Stock	In Stock
50 mg	$496	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$129	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.
Targets&IC50	Antibacterial:125- 500 μg/mL(MIC)
In vitro	Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h[1]

Chemical Properties

Molecular Weight	330.29
Formula	C₁₇H₁₄O₇
Cas No.	529-40-8
Smiles	COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(O)c2=O
Relative Density.	1.507g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (454.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0276 mL	15.1382 mL	30.2764 mL	151.3821 mL
5 mM	0.6055 mL	3.0276 mL	6.0553 mL	30.2764 mL
10 mM	0.3028 mL	1.5138 mL	3.0276 mL	15.1382 mL
20 mM	0.1514 mL	0.7569 mL	1.5138 mL	7.5691 mL
50 mM	0.0606 mL	0.3028 mL	0.6055 mL	3.0276 mL
100 mM	0.0303 mL	0.1514 mL	0.3028 mL	1.5138 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc