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FGF-4 Protein, Mouse, Recombinant

Catalog No. TMPJ-00835
Synonyms: HSTF1, HST-1, FGF4, FGF-4, HBGF-4, Fibroblast growth factor 4, HSTF-1, Heparin-binding growth factor 4, Transforming protein KS3, Heparin secretory-transforming protein 1, KS3, HST

Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FGF-4 Protein, Mouse, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 96.00
50 μg 5 days $ 292.00
500 μg 5 days $ 1,850.00
1 mg 5 days $ 2,800.00
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Biological Description
Technical Params
Product Properties
Description Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
Species Mouse
Expression System E. coli
Tag None
Accession Number P11403
Synonyms HSTF1, HST-1, FGF4, FGF-4, HBGF-4, Fibroblast growth factor 4, HSTF-1, Heparin-binding growth factor 4, Transforming protein KS3, Heparin secretory-transforming protein 1, KS3, HST
Amino Acid Ser67­Leu202
Construction Recombinant Mouse Fibroblast Growth Factor 4 is produced by our E.coli expression system and the target gene encoding Ser67­Leu202 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 15 KDa, reducing conditions
Endotoxin Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.

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Keywords

FGF-4 Protein, Mouse, Recombinant HSTF 1 HSTF1 KS-3 HST-1 FGF4 FGF-4 KS 3 HBGF-4 HBGF 4 HST 1 HBGF4 Fibroblast growth factor 4 HSTF-1 Heparin-binding growth factor 4 FGF 4 Transforming protein KS3 Heparin secretory-transforming protein 1 KS3 HST HST1 recombinant recombinant-proteins proteins protein

 

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