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S1R agonist 2

Name: S1R agonist 2
Brand: TargetMol
SKU: T72059
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72059Cas No. 150085-21-5

S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.

S1R agonist 2

🥰Excellent

Purity: 98.85%

Catalog No. T72059Cas No. 150085-21-5

S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$56	In Stock
10 mg	$89	In Stock
25 mg	$172	In Stock
50 mg	$261	In Stock
100 mg	$386	In Stock
200 mg	$545	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.85%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
Targets&IC50	σ1 receptor:1.1 nM (Ki), σ2 receptor:88 nM (Ki)
In vitro	S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases neurite growth induced by nerve growth factor (NGF) in a dose-dependent manner and has a neuroprotective effect on NMDA stimulation in SHSY5Y cells. At 1 μM (24 hours), it significantly inhibits cell damage induced by Rotenone in SHSY5Y cells and shows no cytotoxicity to A549, LoVo, and Panc-1 cells (0-10 μM; 24-72 hours).[1]

Chemical Properties

Molecular Weight	309.45
Formula	C₂₁H₂₇NO
Cas No.	150085-21-5
Smiles	C(C1CCN(CCCOC2=CC=CC=C2)CC1)C3=CC=CC=C3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (161.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2315 mL	16.1577 mL	32.3154 mL	161.5770 mL
5 mM	0.6463 mL	3.2315 mL	6.4631 mL	32.3154 mL
10 mM	0.3232 mL	1.6158 mL	3.2315 mL	16.1577 mL
20 mM	0.1616 mL	0.8079 mL	1.6158 mL	8.0788 mL
50 mM	0.0646 mL	0.3232 mL	0.6463 mL	3.2315 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6158 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc