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S1R agonist 2

Name: S1R agonist 2
Brand: TargetMol
SKU: T72059
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72059Cas No. 150085-21-5

S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.

S1R agonist 2

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Purity: 99.66%

Catalog No. T72059Cas No. 150085-21-5

S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	-	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$261	-	In Stock
100 mg	$386	-	In Stock
200 mg	$545	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.66%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
Targets&IC50	σ1 receptor:1.1 nM (Ki), σ2 receptor:88 nM (Ki)
In vitro	S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases neurite growth induced by nerve growth factor (NGF) in a dose-dependent manner and has a neuroprotective effect on NMDA stimulation in SHSY5Y cells. At 1 μM (24 hours), it significantly inhibits cell damage induced by Rotenone in SHSY5Y cells and shows no cytotoxicity to A549, LoVo, and Panc-1 cells (0-10 μM; 24-72 hours).[1]

Chemical Properties

Molecular Weight	309.45
Formula	C₂₁H₂₇NO
Cas No.	150085-21-5
Smiles	C(C1CCN(CCCOC2=CC=CC=C2)CC1)C3=CC=CC=C3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (161.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2315 mL	16.1577 mL	32.3154 mL	161.5770 mL
5 mM	0.6463 mL	3.2315 mL	6.4631 mL	32.3154 mL
10 mM	0.3232 mL	1.6158 mL	3.2315 mL	16.1577 mL
20 mM	0.1616 mL	0.8079 mL	1.6158 mL	8.0788 mL
50 mM	0.0646 mL	0.3232 mL	0.6463 mL	3.2315 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6158 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc