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Momordicine I
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Catalog No. TN1940Cas No. 91590-76-0
Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation.
Momordicine I
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Purity: 98.80%
Catalog No. TN1940Cas No. 91590-76-0
Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.80%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation. |
| Targets&IC50 | SVGp12 cells:14.4 μM, LN229 cells:9.2 μM, GBM8401:9.6 μM |
| In vitro | Methods: Momordicine I (0-18 μM, 48 hours) was used to treat SVGp12 astrocytes, LN229 glioma cells, and GBM8401 glioma cells. MTS assay was used to assess cell viability after 48 hours of treatment with specific concentrations. Results: Momordicine I had an inhibitory effect on the above cells with IC50 values of 14.4, 9.2, and 9.6 μM. [1] |
| In vivo | Methods: Momordicine I (30 mg/kg, intraperitoneal injection, once a day for 21 days) was used to treat MOC2-induced xenograft model mice to study its effects on growth and target protein expression in mice. Results: Momordicine I reduced the volume and weight of tumors in mice. It also reduced the expression of Hk1, Pdk3, Fasn, and Acly. [2] |
| Molecular Weight | 472.71 |
| Formula | C30H48O4 |
| Cas No. | 91590-76-0 |
| Smiles | C(=O)[C@]12[C@]([C@@]3(C)[C@](C)(CC1)[C@@]([C@@H](C[C@H](C=C(C)C)O)C)(CC3)[H])([C@@H](O)C=C4[C@]2(CC[C@H](O)C4(C)C)[H])[H] |
| Relative Density. | 1.11 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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