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Momordicine I

🥰Excellent
Catalog No. TN1940Cas No. 91590-76-0

Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation.

Momordicine I

Momordicine I

🥰Excellent
Catalog No. TN1940Cas No. 91590-76-0
Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation.
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1 mg$413In Stock
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Product Introduction

Bioactivity
Description
Momordicine I is a natural cucurbitane-type triterpene exhibiting antihypertensive, anti-inflammatory, anti-hypertrophic, anti-fibrotic, and antioxidant properties. Its mechanisms of action include regulating insulin signalling, inducing cancer cell apoptosis, and modulating NO, ACE, PI3K/Akt, NF-κB, Nrf2, c-Met/STAT3 pathways, and may be applied in cardiovascular diseases and inflammation.
Targets&IC50
LN229 cells:9.2 μM, SVGp12 cells:14.4 μM, GBM8401:9.6 μM
In vitro
Methods: Momordicine I (0-18 μM, 48 hours) was used to treat SVGp12 astrocytes, LN229 glioma cells, and GBM8401 glioma cells. MTS assay was used to assess cell viability after 48 hours of treatment with specific concentrations. Results: Momordicine I had an inhibitory effect on the above cells with IC50 values ​​of 14.4, 9.2, and 9.6 μM. [1]
In vivo
Methods: Momordicine I (30 mg/kg, intraperitoneal injection, once a day for 21 days) was used to treat MOC2-induced xenograft model mice to study its effects on growth and target protein expression in mice. Results: Momordicine I reduced the volume and weight of tumors in mice. It also reduced the expression of Hk1, Pdk3, Fasn, and Acly. [2]
Chemical Properties
Molecular Weight472.71
FormulaC30H48O4
Cas No.91590-76-0
SmilesC(=O)[C@]12[C@]([C@@]3(C)[C@](C)(CC1)[C@@]([C@@H](C[C@H](C=C(C)C)O)C)(CC3)[H])([C@@H](O)C=C4[C@]2(CC[C@H](O)C4(C)C)[H])[H]
Relative Density.1.11 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Momordicine I
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