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Anti-MMP-1 Polyclonal Antibody 2
(Synonyms: matrix metallopeptidase 1, CLGN, CLG) Copy Product Info
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Synonyms: matrix metallopeptidase 1, CLGN, CLG
Catalog No. TMAB-01150 Copy Product Info
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Anti-MMP-1 Polyclonal Antibody 2 is a Rabbit antibody targeting MMP-1. Anti-MMP-1 Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P,WB.
Anti-MMP-1 Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-MMP-1 Polyclonal Antibody 2 is a Rabbit antibody targeting MMP-1. Anti-MMP-1 Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | matrix metallopeptidase 1, CLGN, CLG |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix (Probable). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. |
| Immunogen | KLH conjugated synthetic peptide: human MMP-1 |
| Antigen Species | Human |
| Gene Name | MMP1 |
| Gene ID | |
| Protein Name | Interstitial collagenase |
| Uniprot ID | |
| Biology Area | MMPs,MMPs,MMP,Endothelial mediators/regulators,MMPs,MMP |
| Function | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. |
| Molecular Weight | Theoretical: 27/41/54 kDa. Actual: 54 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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