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VEGFR-2-IN-23

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Catalog No. T61631Cas No. 2411174-53-1

VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an IC50 value of 0.34 nM. It demonstrates significant antitumor activity by inducing apoptosis and causing cell cycle arrest at the G1 phase [1].

VEGFR-2-IN-23

VEGFR-2-IN-23

😃Good
Catalog No. T61631Cas No. 2411174-53-1
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an IC50 value of 0.34 nM. It demonstrates significant antitumor activity by inducing apoptosis and causing cell cycle arrest at the G1 phase [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an IC50 value of 0.34 nM. It demonstrates significant antitumor activity by inducing apoptosis and causing cell cycle arrest at the G1 phase [1].
Targets&IC50
VEGFR2:0.19 nM
In vitro
VEGFR-2-IN-23 (compound 11b) exhibits antitumor activity with IC50 values of 23 nM, 0.8 nM, 1.3 nM, and 46 nM against PC3, DU145, MCF-7, and MDA-MB435 cancer cell lines, respectively [1].
In vivo
VEGFR-2-IN-23, administered intraperitoneally at doses of 5 and 10 mg/kg, effectively suppresses tumor growth in MCF-7 xenograft models [1].
Chemical Properties
Molecular Weight381.39
FormulaC22H15N5O2
Cas No.2411174-53-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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