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Anti-Caspase-12 Polyclonal Antibody 3
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Catalog No. TMAB-03656
Anti-Caspase-12 Polyclonal Antibody 3 is a Rabbit antibody targeting Caspase-12. Anti-Caspase-12 Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
Anti-Caspase-12 Polyclonal Antibody 3
Anti-Caspase-12 Polyclonal Antibody 3
😃Good
Catalog No. TMAB-03656
Anti-Caspase-12 Polyclonal Antibody 3 is a Rabbit antibody targeting Caspase-12. Anti-Caspase-12 Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Caspase-12 Polyclonal Antibody 3 is a Rabbit antibody targeting Caspase-12. Anti-Caspase-12 Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011] |
| Immunogen | KLH conjugated synthetic peptide: the middle of human Caspase-12 |
| Antigen Species | Human |
| Gene Name | CASP12 |
| Gene ID | |
| Protein Name | Inactive caspase-12 |
| Uniprot ID | |
| Function | Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. |
| Molecular Weight | Theoretical: 38 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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