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Spantide acetate

Catalog No. T20413L CAS T20413L

Synonyms: Spantide acetate(91224-37-2 Free base)

Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.

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Spantide acetate, CAS T20413L

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.
In vivo	In examined animals, Spantide acetate (50 nM and 100 nM) all causes a complete respiratory arrest[1]. In female C57BL/6 and BALB/c mice, Spantide acetate (36 μg; i.p.) significantly decreases the number of bacterial counts, perforated corneas, and PMNs. Spantide acetate downregulates the mRNA levels for type I cytokines IFN-γ, IL-6, TNF-α, MIP-2, and IL-1β[2].

Synonyms	Spantide acetate(91224-37-2 Free base)
Molecular Weight	1557.84
Formula	C77H112N20O15
CAS No.	T20413L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15.58 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. M Zubrzycka, et al. Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr Regul. 2000 Mar;34(1):13-8. 2. Linda D Hazlett, et al. Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):797-807. 3. J C Beaujouan, et al. Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br J Pharmacol. 1993 Mar;108(3):793-800.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Spantide acetate T20413L GPCR/G Protein Neuroscience Neurokinin receptor Spantide acetate(91224-37-2 Free base) Inhibitor inhibitor inhibit

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