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Zaurategrast

Name: Zaurategrast
Brand: TargetMol
SKU: T17286
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17286Cas No. 455264-31-0

Alias Zaurategrast, CT-7758, CT7758, CT 7758

Zaurategrast (CDP323) is a small-molecule prodrug antagonist that inhibits the interaction between vascular cell adhesion molecule 1 (VCAM-1) and α4-integrins, originally developed by Celltech plc for oral administration, and it serves as a valuable research compound for investigating leukocyte trafficking, immune cell adhesion, and therapeutic strategies relevant to multiple sclerosis.

Zaurategrast

😃Good

Catalog No. T17286Alias Zaurategrast, CT-7758, CT7758, CT 7758Cas No. 455264-31-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Zaurategrast (CDP323) is a small-molecule prodrug antagonist that inhibits the interaction between vascular cell adhesion molecule 1 (VCAM-1) and α4-integrins, originally developed by Celltech plc for oral administration, and it serves as a valuable research compound for investigating leukocyte trafficking, immune cell adhesion, and therapeutic strategies relevant to multiple sclerosis.
Targets&IC50	α4-integrin:< 100 nM
In vitro	Method: Pharmacokinetic properties of Zaurategrast were assessed using in vitro permeability and uptake assays and in vivo studies in mice, rats, dogs, and cynomolgus monkeys, followed by evaluation of an ethyl ester prodrug. Result: Zaurategrast showed low oral bioavailability in rodents and monkeys due to poor absorption and active hepatic uptake, while the prodrug CDP323 improved permeability and oral bioavailability with effective in vivo conversion[1].
Synonyms	Zaurategrast, CT-7758, CT7758, CT 7758

Chemical Properties

Molecular Weight	521.41
Formula	C₂₆H₂₅BrN₄O₃
Cas No.	455264-31-0
Smiles	N([C@@H](CC1=CC=C(NC=2C3=C(C=CN2)C=CN=C3)C=C1)C(O)=O)C=4C5(C(=O)C4Br)CCCCC5
Relative Density.	1.31g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (153.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9179 mL	9.5894 mL	19.1788 mL	95.8938 mL
5 mM	0.3836 mL	1.9179 mL	3.8358 mL	19.1788 mL
10 mM	0.1918 mL	0.9589 mL	1.9179 mL	9.5894 mL
20 mM	0.0959 mL	0.4795 mL	0.9589 mL	4.7947 mL
50 mM	0.0384 mL	0.1918 mL	0.3836 mL	1.9179 mL
100 mM	0.0192 mL	0.0959 mL	0.1918 mL	0.9589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc