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Zaurategrast

Name: Zaurategrast
Brand: TargetMol
SKU: T17286
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17286Cas No. 455264-31-0

Alias Zaurategrast, CT-7758, CT7758, CT 7758

Zaurategrast (CDP323) is a small-molecule prodrug antagonist that inhibits the interaction between vascular cell adhesion molecule 1 (VCAM-1) and α4-integrins, originally developed by Celltech plc for oral administration, and it serves as a valuable research compound for investigating leukocyte trafficking, immune cell adhesion, and therapeutic strategies relevant to multiple sclerosis.

Zaurategrast

😃Good

Catalog No. T17286Alias Zaurategrast, CT-7758, CT7758, CT 7758Cas No. 455264-31-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Zaurategrast (CDP323) is a small-molecule prodrug antagonist that inhibits the interaction between vascular cell adhesion molecule 1 (VCAM-1) and α4-integrins, originally developed by Celltech plc for oral administration, and it serves as a valuable research compound for investigating leukocyte trafficking, immune cell adhesion, and therapeutic strategies relevant to multiple sclerosis.
Targets&IC50	α4-integrin:< 100 nM
In vitro	Method: Pharmacokinetic properties of Zaurategrast were assessed using in vitro permeability and uptake assays and in vivo studies in mice, rats, dogs, and cynomolgus monkeys, followed by evaluation of an ethyl ester prodrug. Result: Zaurategrast showed low oral bioavailability in rodents and monkeys due to poor absorption and active hepatic uptake, while the prodrug CDP323 improved permeability and oral bioavailability with effective in vivo conversion[1].
Synonyms	Zaurategrast, CT-7758, CT7758, CT 7758

Chemical Properties

Molecular Weight	521.41
Formula	C₂₆H₂₅BrN₄O₃
Cas No.	455264-31-0
Smiles	N([C@@H](CC1=CC=C(NC=2C3=C(C=CN2)C=CN=C3)C=C1)C(O)=O)C=4C5(C(=O)C4Br)CCCCC5
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (153.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9179 mL	9.5894 mL	19.1788 mL	95.8938 mL
5 mM	0.3836 mL	1.9179 mL	3.8358 mL	19.1788 mL
10 mM	0.1918 mL	0.9589 mL	1.9179 mL	9.5894 mL
20 mM	0.0959 mL	0.4795 mL	0.9589 mL	4.7947 mL
50 mM	0.0384 mL	0.1918 mL	0.3836 mL	1.9179 mL
100 mM	0.0192 mL	0.0959 mL	0.1918 mL	0.9589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc