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Anti-PTP1B Antibody (5V912)
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Catalog No. TMAY-00586
Alias PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1
Anti-PTP1B Antibody (5V912) is a Rabbit antibody targeting PTP1B. Anti-PTP1B Antibody (5V912) can be used in ELISA,ICC/IF.
Anti-PTP1B Antibody (5V912)
Anti-PTP1B Antibody (5V912)
😃Good
Catalog No. TMAY-00586Alias PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1
Anti-PTP1B Antibody (5V912) is a Rabbit antibody targeting PTP1B. Anti-PTP1B Antibody (5V912) can be used in ELISA,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PTP1B Antibody (5V912) is a Rabbit antibody targeting PTP1B. Anti-PTP1B Antibody (5V912) can be used in ELISA,ICC/IF. |
| Alias | PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5V912 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of human PTPN1 in A549 and Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-human PTPN1 monoclonal antibody (1:60) at 4°C overnight. Then A549 cells were stained with the Alexa Fluor® 549-conjugated Goat Anti-rabbit IgG secondary antibody (figure A, captured by fluorescence microscope); Hela cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (figure B, captured by laser confocal scanning microscope) , countstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| Application | ELISA,ICC/IF |
| Recommended Dose | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human PTP1B / PTPN1 (rh PTP1B / PTPN1; TMPY-04125; NP_002818.1; Glu 2-Asn 321). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human PTP1B / PTPN1 protein (TMPY-04125) |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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