Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor. Sovesudil shows IC50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil can lower intraocular pressure (IOP) without inducing hyperemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,900.00 | |
50 mg | 8-10 weeks | $ 2,480.00 | |
100 mg | 8-10 weeks | $ 3,890.00 |
Description | Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor. Sovesudil shows IC50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil can lower intraocular pressure (IOP) without inducing hyperemia. |
In vitro | Sovesudil (PHP-201) at a concentration of 1 μM, when administered for 60 minutes, can induce changes in the behavior of human trabecular meshwork (HTM) cells [1]. |
In vivo | Sovesudil, at concentrations of 0.1%, 0.3%, and 0.5%, administered to male New Zealand White rabbits, effectively lowers Intraocular Pressure (IOP) in both normotensive and acute hypertensive conditions without inducing significant hyperemia [1]. |
Molecular Weight | 407.44 |
Formula | C23H22FN3O3 |
CAS No. | 1333400-14-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Sovesudil 1333400-14-8 inhibitor inhibit