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6-Dehydrogingerdione

Name: 6-Dehydrogingerdione
Brand: TargetMol
SKU: TN1171
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1171Cas No. 76060-35-0

Alias 1-Dehydro-6-gingerdione

6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via a reactive oxygen species-mediated mechanism that enhances DR5 expression, up-regulates Ser-15 phosphorylation, and triggers nuclear translocation of p53. Abrogation of p53 using small interfering RNA markedly reduces 6-Dehydrogingerdione-induced DR5 and diminishes TRAIL responsiveness. ROS generation accompanies DR5 activation, and pretreatment with N-acetyl-L-cysteine significantly attenuates these apoptotic responses, confirming 6-Dehydrogingerdione acts through p53-dependent and oxidative stress-mediated apoptotic pathways.

6-Dehydrogingerdione

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Purity: 96.98%

Catalog No. TN1171Alias 1-Dehydro-6-gingerdioneCas No. 76060-35-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	-	In Stock
5 mg	$372	-	In Stock
10 mg	$548	-	In Stock
25 mg	$869	-	In Stock
50 mg	$1,170	-	In Stock
100 mg	$1,570	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:96.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via a reactive oxygen species-mediated mechanism that enhances DR5 expression, up-regulates Ser-15 phosphorylation, and triggers nuclear translocation of p53. Abrogation of p53 using small interfering RNA markedly reduces 6-Dehydrogingerdione-induced DR5 and diminishes TRAIL responsiveness. ROS generation accompanies DR5 activation, and pretreatment with N-acetyl-L-cysteine significantly attenuates these apoptotic responses, confirming 6-Dehydrogingerdione acts through p53-dependent and oxidative stress-mediated apoptotic pathways.
In vitro	6-Dehydrogingerdione (0-150 μM, 24 hours) induced apoptosis in Hep G2 cells in a dose-dependent manner [1].
Synonyms	1-Dehydro-6-gingerdione

Chemical Properties

Molecular Weight	290.35
Formula	C₁₇H₂₂O₄
Cas No.	76060-35-0
Smiles	C(=C/C(CC(CCCCC)=O)=O)\C1=CC(OC)=C(O)C=C1
Relative Density.	1.105 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (275.53 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4441 mL	17.2206 mL	34.4412 mL	172.2060 mL
5 mM	0.6888 mL	3.4441 mL	6.8882 mL	34.4412 mL
10 mM	0.3444 mL	1.7221 mL	3.4441 mL	17.2206 mL
20 mM	0.1722 mL	0.8610 mL	1.7221 mL	8.6103 mL
50 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4441 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc