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Ergosterol

Name: Ergosterol
Brand: TargetMol
SKU: T2912
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2912Cas No. 57-87-4

Alias Provitamin D2, Provitamin D, Ergosterin

Ergosterol is the major sterol in fungi and has anti-inflammatory, antioxidant and antiproliferative properties.

Ergosterol

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Purity: 98.1%

Catalog No. T2912Alias Provitamin D2, Provitamin D, ErgosterinCas No. 57-87-4

Ergosterol is the major sterol in fungi and has anti-inflammatory, antioxidant and antiproliferative properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.1%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Ergosterol AI Summary

Ergosterol exhibits multifaceted bioactivities, including anti-inflammatory, antibacterial, antiviral, and anticancer properties. It inhibits NO production with IC50 values of 27,900 nM in NOX inhibition in fMLP-induced PMN cells and 30,600 nM in iNOS inhibition in mouse BV2 microglial cells, suggesting potential modulation of inflammatory pathways. It demonstrates antibacterial activity against Legionella pneumophila Corby with an MIC of 250.0 µg/mL, and also inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus with inhibition zones of 8.7 mm and 11.2 mm respectively at a concentration of 2 mg/mL. Antiviral activities include inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration, with respective inhibition rates of 11.1% and 0.04%. The compound also shows 2.051% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM concentration. In addition, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 31.68% and 52.34% at 10 µM, respectively. In cancer research, Ergosterol demonstrates cytotoxicity against various cell lines, including mouse L5178Y (EC50: 12,600 nM), human COLO 205 (IC50: 4,900 nM), COLO 320 (IC50: 6,500 nM), and MRC5 (IC50: 500 nM). It shows antiproliferative activity against human NCI-H157 and A549 cells, with IC50 values of 23,300 nM and 19,200 nM, respectively. Significant antitumor activity is observed in xenografted mouse models with Lewis lung cancer cells, with 100% growth inhibition at 12.5 µg/mL after 48 hours and evidence of metastasis inhibition or tumor regression. Despite some toxicity-related net weight reduction, the compound maintains 100% survival rates in treated mouse models. Additionally, Ergosterol exhibits specific bioactivities such as inhibiting TNFalpha-induced NF-kappaB activity in HeLa cells with an IC50 of 0.91 µg/mL and inhibiting human HDAC6 with 26.56% inhibition in an enzymatic assay. However, it shows no activity against UGT1A1 and slight negative inhibition in a custom peptide substrate HDAC6 assay. The compound also potentiates doxorubicin-induced cytotoxicity by inhibiting P-glycoprotein activity in COLO 320 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ergosterol is the major sterol in fungi and has anti-inflammatory, antioxidant and antiproliferative properties.
Synonyms	Provitamin D2, Provitamin D, Ergosterin

Chemical Properties

Molecular Weight	396.65
Formula	C₂₈H₄₄O
Cas No.	57-87-4
Smiles	C[C@@]12[C@](C=3[C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])(CC[C@@]2([C@@H](/C=C/[C@@H](C(C)C)C)C)[H])[H]
Relative Density.	1.04 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble)

Ethanol: < 1 mg/mL (insoluble)

Chloroform: 50 mg/mL (126.06 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

Chloroform

	1mg	5mg	10mg	50mg
1 mM	2.5211 mL	12.6056 mL	25.2111 mL	126.0557 mL
5 mM	0.5042 mL	2.5211 mL	5.0422 mL	25.2111 mL
10 mM	0.2521 mL	1.2606 mL	2.5211 mL	12.6056 mL
20 mM	0.1261 mL	0.6303 mL	1.2606 mL	6.3028 mL
50 mM	0.0504 mL	0.2521 mL	0.5042 mL	2.5211 mL
100 mM	0.0252 mL	0.1261 mL	0.2521 mL	1.2606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc