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MK6-83

Name: MK6-83
Brand: TargetMol
SKU: T24477
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T24477Cas No. 1062271-24-2

Alias MK683

MK6-83 is the transient receptor potential channel ML3 agonist.

MK6-83

🥰Excellent

Purity: 99.5%

Catalog No. T24477Alias MK683Cas No. 1062271-24-2

MK6-83 is the transient receptor potential channel ML3 agonist.

Pack Size	Price	Availability
2 mg	$41	In Stock
5 mg	$66	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$345	In Stock
100 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock

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Batch Information

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Purity:99.5%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MK6-83 is the transient receptor potential channel ML3 agonist.
In vitro	MK6-83(0.2-30 μM) shows no signs of cytotoxicity[1]. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts[1].
Synonyms	MK683

Chemical Properties

Molecular Weight	336.47
Formula	C₁₆H₂₀N₂O₂S₂
Cas No.	1062271-24-2
Smiles	Cc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
Relative Density.	1.311 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (66.87 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9720 mL	14.8602 mL	29.7203 mL	148.6017 mL
5 mM	0.5944 mL	2.9720 mL	5.9441 mL	29.7203 mL
10 mM	0.2972 mL	1.4860 mL	2.9720 mL	14.8602 mL
20 mM	0.1486 mL	0.7430 mL	1.4860 mL	7.4301 mL
50 mM	0.0594 mL	0.2972 mL	0.5944 mL	2.9720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc