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MK6-83

🥰Excellent
Catalog No. T24477Cas No. 1062271-24-2
Alias MK683

MK6-83 is the transient receptor potential channel ML3 agonist.

MK6-83

MK6-83

🥰Excellent
Purity: 99.5%
Catalog No. T24477Alias MK683Cas No. 1062271-24-2
MK6-83 is the transient receptor potential channel ML3 agonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$41In StockIn Stock
5 mg$66In StockIn Stock
10 mg$97In StockIn Stock
25 mg$197In StockIn Stock
50 mg$345In StockIn Stock
100 mg$589In StockIn Stock
1 mL x 10 mM (in DMSO)$73In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.5%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
MK6-83 is the transient receptor potential channel ML3 agonist.
In vitro
MK6-83(0.2-30 μM) shows no signs of cytotoxicity[1]. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts[1].
SynonymsMK683
Chemical Properties
Molecular Weight336.47
FormulaC16H20N2O2S2
Cas No.1062271-24-2
SmilesCc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
Relative Density.1.311 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.5 mg/mL (66.87 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.94 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9720 mL14.8602 mL29.7203 mL148.6017 mL
5 mM0.5944 mL2.9720 mL5.9441 mL29.7203 mL
10 mM0.2972 mL1.4860 mL2.9720 mL14.8602 mL
20 mM0.1486 mL0.7430 mL1.4860 mL7.4301 mL
50 mM0.0594 mL0.2972 mL0.5944 mL2.9720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRPVChannelTRPV ChannelTRPML1TRPChannelTRP ChannelTransient receptor potential channelsMucolipidosisMK6-83MK-6-83MK-683MK6 83MK 683lysosomeInhibitorinhibitfibroblastcell
Related Tags: buy MK6-83 | purchase MK6-83 | MK6-83 cost | order MK6-83 | MK6-83 chemical structure | MK6-83 in vitro | MK6-83 formula | MK6-83 molecular weight
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